Trifluoromethylcoumarin
WebA potent, orally active inhibitor of DPP-4. As an orally active agent, Sitagliptin phosphate exhibits a potent inhibitory effect on DPP-4 with IC50 of 19 nM from Caco-2 cell extracts. [1] MK0431 reduces in vitro migration of isolated splenic CD4 T-cells through a pathway involving cAMP/PKA/Rac1 activation. [2] WebCAS: 575-03-1: Molecular Formula: C10H5F3O3: Molecular Weight (g/mol) 230.142: MDL Number: MFCD00037578: InChI Key: CCKWMCUOHJAVOL-UHFFFAOYSA-N: Synonym: 7-hydroxy-4-trifluoromethyl coumarin, 7-hydroxy-4-trifluoromethylcoumarin, 7-hydroxy-4-trifluoromethyl-2h-chromen-2-one, 7-hydroxy-4-trifluoromethyl chromen-2-one, 4 …
Trifluoromethylcoumarin
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WebDec 1, 2024 · Recently, the effects of antibacterial peptides are suggested to have therapeutic potential in Alzheimer’s disease. Furthermore, systemic treatment of Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) induced Alzheimer’s disease-like neuropathological changes in middle-aged mice. Then, we examined whether … WebEvaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450… A. Renwick , G. Lavignette , +6 authors D. C. Evans
WebA series of seven new derivatives were prepared from 7-hydroxy-4-methyl coumarin, following its oxidation via selenium oxide in hot xylene to form 7-hydroxy-4-formyl coumarin 1. The chalcones 2-4 were prepared from the condensation of 1 with different aromatic ketones at room temperature using 10% NaOH solution.Refluxing equimolar quantities of … WebJan 10, 2024 · Chemsrc provides coumarin 481(CAS#:41934-47-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coumarin 481 are included as well.
WebProduct Description. 7-Methoxy-4- (trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs). 1 Upon enzymatic cleavage by CYPs, 7-hydroxy-4- (trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively. WebThe assay utilizes the synthetic peptide substrate DEVD-AFC (AFC, 7-amino-4-trifluoromethylcoumarin). Active caspase-3 cleaves the synthetic substrate to release free AFC, which can then be quantified by fluorometry. Compounds to be screened can be directly added to the reaction, ...
WebMW 244.17, Purity > 99%. Fluorescent substrate for oxidoreductases, especially for Cytochrome P450. Achieve your results faster with highly validated, pure and trusted …
Web1. The metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin (BFBFC) to 7-hydroxy-4-trifluoromethylcoumarin (HFC) was studied in human liver … masshouseWebis a critical component of the successful development of this methodology. Our initial studies with chiral tin(IV),[11] copper(II),[7] and scandium(III)[5a,12] complexes afforded only low selectivity and/or low reactivity for the synthesis of spirocyclopentane 4a (e.g. masshouse circus roadWebApr 24, 1998 · 7-Ethoxy-4-trifluoromethylcoumarin (ETFMC) is a useful substrate for the determination of certain cytochrome P450 (CYP) enzyme activities, such as CYP2B6 1, 2, … hydrophone amplifierWebGly-Phe-AFC is a fluorogenic, cell-permeant peptide substrate, used in Cytotoxicity testing. In vitro cytotoxicity testing has become an integral aspect of drug discovery because it is a convenient, costeffective, and predictive means of characterizing the toxic potential of new chemical entities. It is also used as substrate for measuring ... masshouse plazamass house for saleWebMethylcoumarin is one of a series of isomers in which a methyl group substitutes for a hydrogen atom in coumarin. They all have formula C 10 H 8 O 2 and molecular weight 160.172 g/mol. name. derivatives. masshouse birminghamWeb7-benzyloxy-4-trifluoromethylcoumarin. 7-benzyloxy-4-trifluoromethylc. oumarin. Molecular Formula CHFO. Average mass 320.263 Da. Monoisotopic mass 320.066040 Da. ChemSpider ID 741653. mass house budget