2024 Myh6-creer

Myh6-creer

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August undefined, 2024

Web27 apr. 2024 · 005657 B6.FVB(129)- A1cf Tg(Myh6-cre/Esr1*)1Jmk /J The alpha-MHC-MerCreMer (αMHC-MerCreMer) transgene has the mouse cardiac-specific alpha-myosin … WebDrd5flox/flox, Myh6 CreERT2 疾病概述慢性心力衰竭（Chronic heart failure, CHF）是由于心脏结构或功能异常导致心室充盈或射血能力受损的复杂临床综合征, 是多种心脏病终 …

Analysis of Cre-mediated genetic deletion of Gdf11 in ... - PubMed

Web20 okt. 2024 · MYH6-CreER tam mice (no. 005657) and STAT3 flox/flox mice (no. 016923) from The Jackson Laboratory used for breeding various genotyping mice (see Supporting Information for detailed procedures). All procedures were approved by the Zhejiang University Institutional Animal Care and Use Committee and are in compliance with NIH … Web20 mrt. 2024 · Myh6-CreER mice were crossed with ARG 2 f/f mice to get Myh6-CreER; ARG 2 loxp/loxp (Myh6-ARG 2-/-). Tamoxifen (Sigma-Aldrich) was prepared in sesame oil (Sigma-Aldrich) and was intragastrically administered to the adult mice (100 mg/kg body weight/day, 8 weeks old) for 5 consecutive days. melon cut in half

Myh6-creERT2小鼠是什么？_百度文库

WebB6.FVB(129)-Tg(Myh6-cre/Esr1) 疾病概述: cre工具小鼠: 实验动物背景信息: C57BL/6J . 模型制作方法: 转基因小鼠. 模型表型数据: 通过研究发现，转基因小鼠经诱导在心肌细胞特异 … Web18 jan. 2024 · Quantitative RT-PCR, immunohistochemistry, and genetic lineage mapping using Myh6 CreER; Rosa26 RmT/mG mice revealed this reflected loss of pulmonary vein cardiomyocytes. The greatest loss of cadiomyocytes was seen within the lung followed by a graded loss beginning at the hilum and extending into the left atrium. nasa honor award criteria

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Web21 feb. 2024 · 一、品系介绍：Cre-ERT2小鼠是一类含有雌激素受体（estrogen receptor，ER）的配体结合区突变体（ERT）与Cre重组酶的融合蛋白表达的小鼠。Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发 … Web22 mrt. 2024 · Myh6-CreER mice were purchased from Jackson Laboratory (stock number: 005657, B6129-Tg (Myh6-cre/Esr1)1Jmk/J). Floxed ARG 2 (ARG 2 f/f) mice were generated by Shanghai Model Organisms Center, Inc. The mice were maintained in a 12 h light/dark cycle at with relative humidity of . Food and water were supplied ad libitum. nasa home and city pixel placementWeb9 sep. 2024 · Myh6 encodes one of two myosin heavy chain proteins for cardiac contraction 32, and the Myh6 promoter has been used to express Cre or CreER in cardiomyocytes. Tg(Myh6-cre)2182Mds drives ... melon cycling glasses

"Web7 sep. 2024 · Myh6-CreER mice (TM-inducible Cre recombinase under the control of Myh6 CM–speciﬁc promoter; the Jackson Laboratory). Homologous recombination in CMs was achieved by administering 3 w eeks of TM " - Myh6-creer

Myh6-creer

WebMyh6 人类同源基因 MYH6 品系描述将Cre插入到大鼠Myh6基因起始密码子处。你也可能感兴趣 Tamoxifen诱导Cre-ERT2小鼠使用指南 Cre-ERT2在无Tamoxifen诱导的情况下， … WebSince high doses of TM, administered as i.p. bolus injections, have been reported to induce myocardial dysfunction in mice carrying the Myh6-CreER allele (26,27), we adopted a 3-week TM diet...

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Web启动子：Myh6 靶基因信息：Cre recombinase，Cre(Cyclization Recombination Enzyme,即环化重组酶）是来源于噬菌体P1的一种酶蛋白，分子量约38kDa。它可以识别催化两 … Web20 sep. 2024 · Myh6, also known as αMHC, Myhc and Myhca, encodes the cardiac muscle specific protein, alpha-myosin heavy chain, which is dynamically expressed in cardiomyocytes and with significant importance for heart development (Carniel et al. 2005; Ching et al. 2005; Posch et al. 2011; Ng et al. 1991 ).

Web21 mrt. 2024 · MYH6 (Myosin Heavy Chain 6) is a Protein Coding gene. Diseases associated with MYH6 include Cardiomyopathy, Dilated, 1Ee and Atrial Septal Defect 3.Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and PAK Pathway.Gene Ontology (GO) annotations related to this … WebCre是一种识别特异位点的基因重组酶，Cre酶的基因序列来源于P1噬菌体的环化重组酶（ c yclization re combinase）， Cre 的名字也源于此。 Cre酶可识别一段名为Loxp的特定基因序列。 Loxp序列长34个碱基，包括中间8碱基的不对称序列，以及两侧反向回文的13碱基序列。 Loxp序列由不对称的中间8bp和回文对称的两侧13bp组成，N碱基表示该位置可以是 …

WebCSS750-H11-Myh6-CreER应用于研究领域:暂无 Web7 mei 2024 · Bitransgenic Myh6 CreER; R26 RmT/mG mice were injected intraperitoneally with tamoxifen (200 μg/mouse) or corn oil vehicle on the morning of birth and then exposed to room air or hyperoxia through PND 4. Some mice were injected intraperitoneally with mitoTEMPO (0.7 μg/g) or vehicle on PND 0, PND 1, and PND 2.

Web13 dec. 2024 · We previously demonstrated the non-redundant role of Tead1 at both proliferative and postproliferative stages using constitutive and inducible myosin-heavy-chain 6 (Myh6) pro- moterdrivencardiomyocyte-speciﬁcTead1-knockoutmodels(18, 19). In adult mice, induction of Tead1 deletion in cardiomyocytes resulted in impaired systolic function …

Web7 sep. 2024 · Europe PMC is an archive of life sciences journal literature. melon cutting knifeWeb011038 B6.FVB-Tg(Myh6-cre)2182Mds/J The cardiac-specific alpha myosin-heavy chain ( Myh6 ) promoter drives expression of cre in this transgenic strain. The promoter induces greater than 90% recombination in cardiac muscle cells. nasa history of solar system understandingWebCre是一种识别特异位点的基因重组酶，Cre酶的基因序列来源于P1噬菌体的环化重组酶（ c yclization re combinase）， Cre 的名字也源于此。 Cre酶可识别一段名为Loxp的特定基 … melon dicer hypixel skyblock priceWeb1 jul. 2024 · First, whole heart Gdf11 expression did not decrease in Myh6-cre; Gdf11 -floxed mice, possibly because of upregulation of Gdf11 in noncardiomyocytes in the heart. Second, we observed Cre-associated toxicity, with lower body weights and increased global fibrosis, in Cre-only control male mice compared with flox-only controls, making it ... melon dicer hypixelWeb5 sep. 2024 · To detect the Pf4-Cre and Myh6-CreER T2 transgenes, we used primers EiCre1 (5′-GACAGGCAGGCCTTCTCTGAA-3′) and EiCre2 (5′-CTTCTCCACACCAGCTGTGGA-3′), which amplify a 522-bp fragment 52. nasa home and city 2.0WebMyh6-CreER mice were crossed with ARG 2f/f mice to get Myh6-CreER; ARG 2loxp/loxp (Myh6-ARG 2-/-). Tamoxifen (Sigma-Aldrich) was prepared in sesame oil (Sigma-Aldrich) and was intragastrically administered to the adult mice (100mg/kg body weight/day, 8 weeks old) for 5 consecutive days. 2.4. EA Treatment. nasa hls program officeWebB6.FVB(129)-Tg(Myh6-cre/Esr1) 疾病概述: cre工具小鼠: 实验动物背景信息: C57BL/6J . 模型制作方法: 转基因小鼠. 模型表型数据: 通过研究发现，转基因小鼠经诱导在心肌细胞特异性表达Cre重组酶。动物模型的评价与验证: 主要用来跟flox小鼠杂交，而达到特异性敲除的目的 ... nasa hoodie south africa