2024 Lamp2 lamp2a

Lamp2 lamp2a

Author: jfbp

August undefined, 2024

Tīmeklis2024. gada 25. marts · Here, we describe a mechanism whereby proteins containing a KFERQ motif pentapeptide are loaded into a subpopulation of exosomes in a process that is dependent on the membrane protein LAMP2A. Moreover, we demonstrate that this mechanism is independent of the ESCRT machinery but dependent on HSC70, … TīmeklisLAMP1 (lysosomal-associated membrane protein 1) and LAMP2 are the most abundant protein components of lysosome membranes. Both LAMPs have common structures consisting of a large lumenal domain composed of two domains (N-domain and C-domain, which are membrane-distal and -proximal, respectively), both with the β …

LAMP2A抗体- Lysosome Marker Abcam中文官网

Tīmeklis2024. gada 8. febr. · LAMP2A decrease enhances the lysosomal damage induced by lysosomotropic agents, ultimately leading to cell death. The effect is cancer-specific, as JNK inhibition does not decrease LAMP2A in... TīmeklisLysosome-associated membrane protein 1 and 2 (LAMP1 and LAMP2) are two abundant lysosomal membrane proteins (1,2). Both are transmembrane proteins and are heavily glycosylated at the amino … harbor freight cabinet scraper

Unique properties of lamp2a compared to other lamp2 isoforms

Tīmeklis2024. gada 18. marts · LAMP2 has three isoforms: LAMP2A, LAMP2B, and LAMP2C. LAMP2B is the predominant isoform expressed in cardiomyocytes. This study … Tīmeklis2024. gada 25. marts · Here, we describe a mechanism whereby proteins containing a KFERQ motif pentapeptide are loaded into a subpopulation of exosomes in a … TīmeklisLAMP2A functions as a receptor of chaperone-mediated autophagy (CMA), in which cytoplasmic proteins are transported into lysosomes for degradation [ 10 ]. LAMP2B … chances of falling pregnant at 48

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated …

Genetic LAMP2 deficiency accelerates the age-associated ... - PNAS

TīmeklisLysosomal-associated membrane protein 2 (LAMP2, synonyms: LAMPB, CD107b) is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. LAMP2 may plays a role in tumor cell metastasis. It may also functions in the protection, maintenance, and adhesion of the lysosome. Tīmeklis2024. gada 24. nov. · Lysosomal p38 MAPK directly phosphorylates the CMA receptor LAMP2A at T211 and T213, which causes its membrane accumulation and active … harbor freight cable cuttersLAMP-2A is the receptor for chaperone-mediated autophagy. Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis. LAMP-2B is associated with Danon disease . Structure and tissue … Skatīt vairāk Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C-terminal sequence: in the luminal domain, … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Cluster of differentiation Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the cell. Some of this is done via acid … Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of … Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and Homeostatic Agents. 16 (2): 147–51. PMID 12144129. • Schleutker J, Haataja L, Renlund M, Puhakka L, Viitala J, Peltonen L, … Skatīt vairāk chances of false positive herpes test

"Tīmeklis2024. gada 7. nov. · LAMP2 expression in the retina and the RPE in young and aged mice. ( A) Western blot analyses of LAMP2 expression in the retina or the … " - Lamp2 lamp2a

Lamp2 lamp2a

Recombinant Anti-LAMP2A antibody [EPR4207(2)] - Lysosome Marker ... - Abcam

Tīmeklis2024. gada 9. marts · Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure. These results suggest that VPS35 deficiency or mutation promotes Parkinson Disease (PD) pathogenesis, and reveals a crucial pathway, VPS35-Lamp2a-alpha-synuclein, to prevent PD pathogenesis. Tīmeklis2024. gada 12. nov. · Abstract. Lysosome-associated membrane protein type 2A (LAMP2A) is a key protein in the chaperone-mediated autophagy (CMA) pathway. …

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TīmeklisLAMPB; CD107b; LAMP-2; LGP110; LAMP2 Category Apoptosis Background Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. ... LAMP2a Rabbit Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效 … Tīmeklis2024. gada 27. sept. · LAMP-2 Antibody (H4B4) is an IgG 1 κ mouse monoclonal LAMP-2 antibody (also designated LAMP2 antibody, LAMPB antibody or lysosomal associated membrane protein 2 …

Tīmeklis从下图我们可以获知，微自噬和cma的共同点是需要hsc70这个伴侣蛋白的参与，且一般底物蛋白序列中有“kferq”基序。不同点在于，cma过程更复杂，且参与蛋白更多。其 … TīmeklisJ:332686 Rodrigues PM, et al., LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development. Autophagy. 2024 Feb;19(2):426-439) Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly …

TīmeklisIn this work, we identified and validated 2 NFE2L2 binding sequences in the LAMP2 gene and demonstrated in several human and mouse cell types that NFE2L2 deficiency and overexpression was linked to reduced and increased LAMP2A levels, respectively. Accordingly, lysosomal LAMP2A levels were drastically reduced in nfe2l2-knockout … TīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate …

TīmeklisDescription Rat monoclonal [GL2A7] to LAMP2 Host species Rat Tested applications Suitable for: IHC-Fr, ICC, ICC/IF, IHC-FoFr, IP, Flow Cyt, WB, IHC-P more details Species reactivity Reacts with: Mouse, Rabbit, Human Immunogen Tissue, cells or virus corresponding to Mouse LAMP2. Purified preparation of mouse liver lysosomal …

TīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. chances of false pregnancy testTīmeklisIsoform LAMP-2C Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of … harbor freight camera probeTīmeklisLAMP2a (Homo sapiens) Blum Add to Cart 89342: pcDNAZeo(-) LAMP2C: Lysosomal-associated membrane protein 2C (Homo sapiens) Blum Add to Cart 154151: pBoBi … harbor freight cable swageTīmeklis2024. gada 24. nov. · Lysosomal p38 MAPK directly phosphorylates the CMA receptor LAMP2A at T211 and T213, which causes its membrane accumulation and active conformational change, activating CMA. ... myc-wt-LAMP2, mt ... chances of father getting 50/50 custody ukTīmeklis2000. gada 15. dec. · Lamp2a acts as a receptor in the lysosomal membrane for substrate proteins of chaperone-mediated autophagy. Using antibodies specific for the cytosolic tail of lamp2a and others recognizing all lamp2 isoforms, we found that in rat liver lamp2a represents 25% of lamp2s in the lysosome. We show that lamp2a … chances of father getting full custodyTīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. harbor freight cabinet with storage drawersTīmeklisLUXA2 believes that simplicity is the ultimate sophistication. Our design starts from a simple concept. harbor freight camera and dvr