WebOct 30, 2024 · Equilibrium Solubility Measurements. 2 = 0.9993) over this concentration range. UV/Vis Extinction Measurements. UV extinction measurements were used to determine the onset of liquid-liquid phase separation (LLPS) in supersaturated posaconazole solutions in FaSSIF. 50 mL of FaSSIF was stirred at 300 rpm and … WebMay 17, 2024 · Our review found that SGF was used with the shake-flask method in 17.4% cases (8 of 46 studies) (13,15,17,21,26,40,41,49) and in 10.0% ... The solubility of the …
Biorelevant solubility of poorly soluble drugs ... - ScienceDirect
WebSGFsp (Simulated Gastric Fluid sine pepsin) was adjusted to pH 2 rather than pH 1.2 in order to reduce a substantial decrease in pH during the in vitro transfer of SGF into FaSSIF (final pH of... http://dissolutiontech.com/DTresour/200405Articles/DT200405_A03.pdf barbara davidson
Dissolution behavior of various drugs in different FaSSIF …
WebOct 4, 2010 · The acidic compounds displayed clear pH dependency, although the higher concentration of solubilizing agents in FeSSIF than FaSSIF also improved the solubility. … WebAug 29, 2014 · The equilibrium solubility experiments for the selected pyrazole derivatives were performed in five media simulating different segments of the GI tract (three aqueous solutions—SGF, SIF and pH 4.5 acetate buffer) and two biorelevant media containing physiological surface active agents (FaSSIF and FeSSIF). WebMay 1, 2024 · Finally, two case studies that highlight PK variability issues are described, and successful mitigation strategies are presented. Keywords: AUC; FaSSIF; SGF; exposure; lipophilicity; permeability; pharmacokinetics; preclinical; solubility; variability. MeSH terms Animals Area Under Curve Body Fluids / metabolism Dogs barbara davies savannah ga