2024 Diversity outbred

Diversity outbred

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August undefined, 2024

WebSep 14, 2024 · The JAX Diversity Outbred (J:DO) mice, for example, is a unique platform to test therapeutic interventions in a population that models the diversity seen in a human population. The JAX Diversity Mouse Portfolio. Here, we present the JAX Diversity Mouse Portfolio. These diversity models were generated with different breeding strategies, … WebThe Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically …

Inbred or Outbred? Genetic Diversity in Laboratory Rodent …

WebDec 13, 2024 · We also show that genetic diversity in allegedly “outbred” colonies of nonmodel rodents (gerbils, hamsters, house mice, deer mice, and rats) varies considerably from nearly no segregating diversity to very high levels of polymorphism. We conclude that genetic divergence in isolated colonies may play an important role in the “replication ... WebAug 17, 2024 · Author summary More humans die of tuberculosis (TB) than any other infectious disease, yet diagnostic tools remain limited. Here, we used the Diversity Outbred mouse population to discover candidate protein biomarkers of human TB. By applying statistical methods and machine learning to multidimensional data, we identified CXCL1 … how is a thylakoid different from a granum

High-Resolution Genetic Mapping in the Diversity Outbred …

WebThe Diversity Outbred captures a vast background of allelic variants in a highly recombinant population. Each DO animal is unique and not reproducible, which … WebDiversity Outbred mice. Advantages. They reveal dominance and epistasis attributable to heterozygosity and randomized multi-locus combinations. More advanced … WebThe JAX Diversity Outbred (J:DO) mice, for example, is a unique platform to test therapeutic interventions in a population that models the diversity seen in a human population. The JAX Diversity Mouse Portfolio. Here, we present the JAX Diversity Mouse Portfolio. These diversity models were generated with different breeding strategies, … how is a thunderstorm formed

Diversity Outbred: A New Generation of Mouse Model

Getting Started with Diversity Outbred Mice - jax.org

WebThis MiniCourse is self-paced and takes 3 to 5 hours to complete. At the end of the MiniCourse, you will be able to define genetically diverse mouse models, the Collaborative Cross (CC) and the Diversity Outbred (DO). These two complementary multi-parent mouse model populations are actually much more powerful than human genetic studies for ... WebMar 3, 2024 · The Diversity Outbred (DO) mice were derived from CC mice outcrossed to maintain the distribution of alleles from across the eight parental strains in a unique combination in each mouse (Chesler et al., 2016; Saul et al., 2024; Svenson et al., 2012). Each DO mouse is unique, and the population is heterogeneous, giving theoretically … high lactate valuesWebOct 23, 2014 · An alternative approach is the use of multi-parental outbred lines for genetic mapping, such as the Diversity Outbred (DO) mouse panel, which can be more informative than traditional two-parent ... how is a thyroid biopsy done

"WebThe Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically … " - Diversity outbred

Diversity outbred

WebApr 15, 2024 · In contrast, Diversity Outbred (DO) mice are a new population whose level of genetic diversity is on par with that of humans and nonhuman primates (NHPs) . The eight founding inbred strains that comprised the initial breeding pool for DO mice included traditional laboratory strains such as B6 and A/J, as well as three wild-caught mouse … WebThe diversity outbred (DO) is a highly engineered mouse population derived from eight genetically diverse inbred founders (A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, …

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WebApr 12, 2024 · In the Smith Lab in MGM, she now leverages genetically diverse mice including well-known inbred lines, recombinant inbred panels (BXD, Collaborative Cross), and outbred panels (Diversity Outbred) to explore the many ways in which variation between unique individuals can predict TB disease outcomes.

WebDODB is a database that provides access to genotype and phenotype data from experiments with Diversity Outbred mice. Data can be searched by publication, investigator, and data type and can be downloaded in zipped CSV or R/QTL2 formats. Users can download full studies or a subset of samples, genotypes, clinical phenotypes and … WebJan 25, 2024 · It is unclear how standing genetic variation affects the prognosis of prostate cancer patients. To provide one controlled answer to this problem, we crossed a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice, a collection of animals that carries over 40 million SNPs. Inte …

WebThe scientists found that, like humans, each Diversity Outbred mouse developed at The Jackson Laboratory, Bar Harbor, Maine, responded to the effects of the chemical exposure differently. Exposure responses were … WebWhile both outbred stocks offer significant individual heterozygosity, our data provide a molecular basis for their intended applications, where the J:DO are best suited for …

WebApr 20, 2024 · To investigate this, we utilized the Diversity Outbred (DO) and Collaborative Cross (CC) mouse models. DO mice are an outbred stock generated by crossbreeding eight inbred founder strains, and CC mice are recombinant inbred mice generated from the same eight founders. We generated 207 DOB6F1 mice representing 48 DO dams and …

WebSince our 2012 NAR report, we have added >70 new data sets, including data from Collaborative Cross lines and Diversity Outbred mice. During this time we have completely revamped our homepage, improved search and navigational aspects of the MPD application, developed several web-enabled data analysis and visualization tools, … how is a thunder egg formedWebNov 4, 2024 · To determine the effect of genetics on plasma protein levels in human, one needs a rather large sample size. To overcome this critical issue, a mouse model, the Diversity Outbred (DO), was established that is genetically as diverse as the human population. In this study, we used N=140 DO mice and genotyped over 140,000 variants. how is a thrift savings plan taxedWebThe Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically … how is a thyroid biopsy performedWebEvaluate Diversity Outbred (DO) mice as a tool for exposure threshold assessment and for identification of genetic factors that influence benzene-induced genotoxicity. Appraise … how is a thunderstorm madeWebDec 2, 2024 · Here, we investigate the impact of genetic regulation on sex-specific gene expression using Diversity Outbred (DO) mice, an outbred population derived from eight inbred mouse strains [57, 58]. DO mice have high natural allelic variance [59, 60] and diverse phenotypes [61, 62], which facilitates fine genetic mapping of liver-specific traits. how is a thunderstorm createdWebThis MiniCourse is self-paced and takes one to two hours to complete. At the end of the MiniCourse, you will be able understand how the Diversity Outbred (DO) can be used in … how is a thyroid nodule removedWebtumor, Wei lab established a novel gene discovery platform of Diversity Outbred (DO) F1 mice that express HER2/Neu oncogene. Each mouse carries individually unique genetic composition that enables high-resolution linkage between genotype and phenotype. Using this platform, regulatory genes of tumor progression and vaccine response have been how is a thyroid fna performed